07/12/05 From: TAP Pharmaceutical ---- Prevacid                                                  Here is some information that can help your patients with GERD. PREVACID is FDA approved for GERD in adolescents 12-17 years old, in addition to children 12 months-11 years old. PREVACID provides the most FDA-approved oral administration options of any PPI including strawberry-flavored PREVACID SOLUTAB (lansoprazole), the only PPI available an orally disintegrating tablet. PREVACID SOLUTAB is bioequivalent to PREVACID capsules, and it's easy to take. SoluTab quickly disintegrates in the mouth-with or without water-usually in less than 60 seconds. And PREVACID SoluTab can be administered in three different ways: -Orally disintegrating tablet -Nasogastric tube (> 8 French) -Oral syringe The safety and effectiveness of PREVACID have been established in patients 1 o 17 years of age for the short-term treatment of symptomatic and erosive GERD. Individual results may vary. Use of PREVACID in this age group is supported by evidence from adequate and well-controlled studies in adults along with additional clinical and PK/PD studies performed in pediatric patients. The pediatric studies were uncontrolled open-label studies performed in 66 patients aged 1 to 11 years old and 87 patients aged 12 to 17 years old. The safety and effectiveness of PREVACID have not been established in patents <1 year of age. The most frequently reported adverse events in patients aged 1 to 11 years old were constipation (5%) and headache (7%), abdominal pain (5%), nausea (3%), and dizziness (#%). In adults, the most frequently reported adverse events were diarrhea (3.8%), abdominal pain (2.1%), and nausea (1.3%). Symptomatic response to therapy does not preclude the presence of gastric malignancy. PREVACID is contraindicated in patients with known hypersensitivity to any component of the formulation. For additional information about Prevacid SoluTab, including details on administration options, please see the accompanying complete prescribing information for PREVACID, contact your TAP representative, visit www.prevacid.com, or call TAP Medical Information at 1-800-622-2011. Sincerely, Lawrence Staubach, MD Director, Medical Affairs P.S. PREVACID delivers comforting relief to more kids, in more ways. For ordering information, contact your wholesaler today!