March  2002                                                                                           

From: Seroo

Dear Pharmacist:

Serono is pleased to announce a new addition to our family of recombinant products, Rebif® (interferon beta-1a), Rebif® is available as a Pack Size of 12 pre-filled syringes per unit in 22 mcg Starter Kit and 44 mcg strengths.

Indications and Usage

Rebif® (interferon beta-la) is indicated for the treatment of patients with relapsing forms of multiple sclerosis to decrease the frequency of clinical acerbations and delay the accumulation of physical disability.  Efficacy of Rebif® in chronic progressive multiple sclerosis has not been established.

Contact your wholesaler for ordering information, or call Serono Customer Service at 888-398-4567.

For information on how Rebif® (interferon beta-la) may be appropriate for your Multiple Sclerosis patients, or for reimbursement assistance, contact Serono toll free at 1-877-44Rebif (877-447-3243) or www.Rebif.com.

Rebif® TRADE LAUNCH SHEET

Special Introductory Terms May Apply.  Please contact your wholesaler for information, or call Serono Customer Service at 888-398-4567.

Product Strength       NDC 44087P       Packet Size       Unit Case Size       WAC             AWP       

Rebif® 22 mcg            0022-3                   12 prefilled                       1              $1,067.30      $1,334.1

Starter Pack                                             syringes in 1 unit

Rebif® 44 mcg          0044-3                      12 prefilled                       1             $1,067.30       $1,334.1

                                                                syringes in 1 unit

THERAPEUTIC CLASS

Multiple Sclerosis

STORAGE AND STABILITY

Rebif® should be refrigerated between 2° - 8° (36° - 46° F). DO NOT FREEZE.  If a refrigerator is temporarily not available, such as while you are traveling, Rebif should be kept in a cooler, below (25°C/77°F)  and away from heat and light.

Do not use beyond the expiration date printed on the packages.  Rebif contains no preservatives.  Each syringe is intended for single use.  Unused portions should be discarded.

DESCRIPTION

Rebif (interferon beta-la) is a purified 166-amino acid glycoprotein with a muscular weight of approximately 22,500 daltrons.  It is produced by recombinant DNA technology as genetically engineered Chinese hamster ovary cells into which the human interferon beta gene has been introduced.  The amino acid sequence of Rebif is identical to that of natural fiberolas-derived human interferon beta.  Natural interferon beta and interferon beta-la (Rebif) are plycosylated, with each containing a single N-linked complex carbohydrate moiety.

INDICATIONS AND USAGE

Rebif (interferon beta-la) is indicated for the treatment of patients with relapsing forms of multiple sclerosis to decrease the frequency of clinical exacerbations and delay the accumulation of physical disability.  Efficacy of Rebif in chronic progressive multiple sclerosis has not been established.

CONTENTS

Each syringe contains interferon beta-la (22 mcg or 44), human serum albumen, mannitol, sodium acetate, and Water for Injection, USP.

DISTRIBUTED BY

Serono, Inc., Randolph, MA 02368