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March 3, 2005

I am writing to you on behalf of MetroGel- Vaginal ( metronidazole vaginal gel) 0.75% Vaginal Gel, the number one prescribed intravaginal treatment for bacterial vaginosis. As you know, the active ingredient in MetroGel-Vaginal is available in other formulations; however, none of these products offers all the benefits MetroGel-Vaginal offers your customers.

Enclosed please find a fact sheet that quickly highlights the efficacy and convenience of MetroGel-Vaginal. You might find it useful in counseling your customers.

We have also enclosed a sample of a proper prescription for MetroGel-Vaginal according to your state's regulations. When filling prescriptions for MetroGel-Vaginal, please be sure that you customer's receive the brand their health care providers have specified.

For more information about MetroGel-Vaginal, please visit our Web site at www.MetroGel-Vaginal.com.

We welcome your inquiries. Thank you for your support.

Sincerely,

Suzanne Hart, Product Manager

The most commonly reported side effects for MetroGel-Vaginal include vaginal discharge (12%), Candida cervicitis/vaginitis (6%-10%), vulvovaginal irritation (9%), gastrointestinal discomfort (7%), and headache (5%).

IMS: National Prescription Audit, Therapeutic Category Report, December 2004.

Please see full prescribing information enclosed.


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