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12/09/04 From Duramed Subsidiary of Barr Pharmaceuticals, Inc. Duramed Pharmaceuticals, Inc., a subsidiary of Barr Pharmaceuticals, Inc., is pleased to announce the acquisition of Plan B (levonorgestrel) tablets, 0.75 mg- now the only marketed emergency contraceptive. Plan B, currently available by prescription, is a progestin-only pill. Since Preven  (levonorgestrel) 0.25 mg/ethinyl estradiol 0.05 mg tablet USP) has been discontinued and is no longer manufactured, Plan B provides a safe and effective alternative for emergency contraception. If you receive any prescription for Preven, you should contact the prescriber and offer Plan B as the safe and effective alternative. Plan B is not an abortifacient; it is not effective if a women is already pregnant. Plan B can prevent pregnancy in cases of contraceptive failure or unprotected intercourse. For optimal efficacy, a woman must take the first tablet as soon as possible within 72 hours and the second tablet 12 hours later. Plan B can reduce the risk of pregnancy by 89% when taken as directed. Each packet of Plan B contains a single, 2 tablet course of treatment. The NDC number is 51285-038-93. Plan B May be appropriate when a woman -Engaged in intercourse without contraception protection -Used a barrier methods of contraception that failed during intercourse or failed to follow their contraceptive regimen -Was raped Plan B broadens the contraceptive options Duramed offers to women. Our sales force will provide you with materials to support the use of Plan B. Information for professionals and patients is available at www.go2planB.com. Our Plan B information line can be accessed toll free at 1-800-330-1271 from 8AM to 7PM EST. Stocking Plan B is the critical first step. Order Plan B now from your wholesaler or call 1-800-330-1271. We hope you will help Duramed Pharmaceuticals provide access to women in need of emergency contraception. Stocking Plan B is especially important, since timing is critical to the efficacy of Plan B. Very Truly Yours, Ericka Higgins Product Manager PS: Coming soon! Duramed Pharmaceuticals will be conducting a full-scale launch of Plan B, complete with new materials for professionals and patients in the near future. In the interim, our sales representatives will be calling on you with patient materials and literature for professionals. Plan B is contraindicated in women with known or suspected pregnancy, hypersensitivity to any component of the product, or undiagnosed abnormal genital bleeding. Plan B is not recommended for routine use as a contraceptive. Plan B is not effective in terminating an existing pregnancy. Plan B does not protect against HIV infection and other sexually transmitted diseases (STDs). Menstrual bleeding may be heavier or lighter after taking Plan B. If menses are delayed beyond one week, pregnancy should be considered. Severe abdominal pain may signal a tubal (ectopic) pregnancy. Common side effects associated with the use of Plan B include nausea, abdominal pain, fatigue, headache, and menstrual changed.

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