June 2005

On behalf of AstraZeneca Pharmaceuticals and the Marketing Team for CRESTOR (rosuvastatin calcium), we cordially invite you to participate in an informative on-demand teleconference, presented  y a national thought leader. The teleconference series is entitled "FDA Rejects Public Citizen's Petition". On March 11, 2005, the FDA formally denied a petition to remove CRESTOR from the market following a thorough analysis of clinical trial safety data and post-marketing data for CRESTOR. This convenient forum will consist of a 20 minute audio presentation, followed by five true and false polling questions; and is available on-demand 24 hours a day, 7 days a week. Under this format, you have the opportunity to listen to the following faculty presenter: Christie M. Ballantyne, MD Professor of Medicine Director, Center for Cardiovascular Disease Prevention Baylor College of Medicine and Methodist DeBakey Heart Center Houston, Texas Participation Instructions 1. By dialing the specified 800 number, you will be required to provide your name, address and telephone number for certificate and tracking purposes. 2. Listen to the pre-recorded presentation while following along with the slides in the brochure. 3. At the conclusion of the 20 minute presentation, you will be asked to answer five questions. TELECONFERENCE NUMBER: 800-901-2812 Should you have any questions or require information, please feel free to contact Domenica Marrella by phone, 888-900-9995, ext 5509, or via e-mail, marrella@scshealthcare.com. Sincerely, The CRESTOR Brand Team

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